Effect of povidone-iodine liposome hydrogel on colonic anastomosis

Ustek S., Kismet K., Akkus M., Ozcan A., Aydogan A., Renda N.

EUROPEAN SURGICAL RESEARCH, vol.37, no.4, pp.242-245, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 4
  • Publication Date: 2005
  • Doi Number: 10.1159/000087870
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.242-245
  • Hacettepe University Affiliated: No


Background: To evaluate the effect of povidone-iodine liposome hydrogel on colonic anastomosis. Methods: 70 Wistar-Albino male rats were randomly divided into seven groups. The left colon was transected and end-to-end anastomosis was performed. PVP-I liposome hydrogel was applied around the anastomoses in groups 2 and 5. Colonic bursting pressures and tissue hydroxyproline contents were measured on postoperative days 3 and 7. Results: PVP-I application did not cause any difference in the bursting pressures on postoperative day 3, but anastomotic strength was significantly increased by the use of PVP-I on postoperative day 7. The use of PVP-I liposome hydrogel had no effect on the level of perianastomotic hydroxyproline on postoperative day 3 but had positive effects on postoperative day 7. Conclusions: We concluded that the beneficial effects of PVP-I liposome hydrogel might be due to the combination of broad-spectrum antimicrobial activity of PVP-I with the drug delivery properties and moisturizing molecular film effects of the liposome hydrogel. Copyright (C) 2005 S. Karger AG, Basel.