HDAC4 mutations cause diabetes and induce -cell FoxO1 nuclear exclusion

Gong, Maolian; Yu, Yong; Liang, Lei; VURALLI KARAOĞLAN, DOĞUŞ; Froehler, Sebastian; Kuehnen, Peter; Du Bois, Philipp; Zhang, Jingling; Cao, Aidi; Liu, Yuantao; Hussain, Khalid; Fielitz, Jens; Jia, Shiqi; Chen, Wei; Raile, Klemens

doi:10.1002/mgg3.602

HDAC4 mutations cause diabetes and induce -cell FoxO1 nuclear exclusion

Gong M., Yu Y., Liang L., VURALLI KARAOĞLAN D. , Froehler S., Kuehnen P., ...More

MOLECULAR GENETICS & GENOMIC MEDICINE, vol.7, no.5, 2019 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 7 Issue: 5
Publication Date: 2019
Doi Number: 10.1002/mgg3.602
Title of Journal : MOLECULAR GENETICS & GENOMIC MEDICINE

Abstract

BackgroundStudying patients with rare Mendelian diabetes has uncovered molecular mechanisms regulating -cell pathophysiology. Previous studies have shown that Class IIa histone deacetylases (HDAC4, 5, 7, and 9) modulate mammalian pancreatic endocrine cell function and glucose homeostasis.