HDAC4 mutations cause diabetes and induce -cell FoxO1 nuclear exclusion


Gong M., Yu Y., Liang L., VURALLI KARAOĞLAN D. , Froehler S., Kuehnen P., ...More

MOLECULAR GENETICS & GENOMIC MEDICINE, vol.7, no.5, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 5
  • Publication Date: 2019
  • Doi Number: 10.1002/mgg3.602
  • Title of Journal : MOLECULAR GENETICS & GENOMIC MEDICINE

Abstract

BackgroundStudying patients with rare Mendelian diabetes has uncovered molecular mechanisms regulating -cell pathophysiology. Previous studies have shown that Class IIa histone deacetylases (HDAC4, 5, 7, and 9) modulate mammalian pancreatic endocrine cell function and glucose homeostasis.