HDAC4 mutations cause diabetes and induce -cell FoxO1 nuclear exclusion


Gong M., Yu Y., Liang L., VURALLI KARAOĞLAN D. , Froehler S., Kuehnen P., ...Daha Fazla

MOLECULAR GENETICS & GENOMIC MEDICINE, cilt.7, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 7 Konu: 5
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1002/mgg3.602
  • Dergi Adı: MOLECULAR GENETICS & GENOMIC MEDICINE

Özet

BackgroundStudying patients with rare Mendelian diabetes has uncovered molecular mechanisms regulating -cell pathophysiology. Previous studies have shown that Class IIa histone deacetylases (HDAC4, 5, 7, and 9) modulate mammalian pancreatic endocrine cell function and glucose homeostasis.