Plasma Phthalate Levels in Pubertal Gynecomastia

durmaz E., ÖZMERT E. N. , ERKEKOGLU P., Giray B., Derman O., Hincal F., ...More

PEDIATRICS, vol.125, no.1, 2010 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 125 Issue: 1
  • Publication Date: 2010
  • Doi Number: 10.1542/peds.2009-0724
  • Journal Name: PEDIATRICS
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Keywords: phthalate, di-(2-ethylhexyl)-phthalate, mono-(2-ethylhexyl)-phthalate, endocrine disrupter, puberty, gynecomastia, N-BUTYL PHTHALATE, SEXUAL-DIFFERENTIATION, TESTOSTERONE SYNTHESIS, GENE-EXPRESSION, MALE-RAT, EXPOSURE, DI-(2-ETHYLHEXYL)-PHTHALATE, TAMOXIFEN, DEHP, DI(2-ETHYLHEXYL)PHTHALATE


OBJECTIVE: Several untoward health effects of phthalates, which are a group of industrial chemicals with many commercial uses including personal-care products and plastic materials, have been defined. The most commonly used, di-(2-ethylhexyl)-phthalate (DEHP), is known to have antiandrogenic or estrogenic effects or both. Mono-(2-ethylhexyl)-phthalate (MEHP) is the main metabolite of DEHP. In this study, we aimed to determine the plasma DEHP and MEHP levels in pubertal gynecomastia cases.