Relationships of Fall Risk With Frailty, Sarcopenia, and Balance Disturbances in Mild-to-Moderate Alzheimer’s Disease

Oytun M. G., TOPUZ S., Baş A. O., ÇÖTELİ S., KAHYAOĞLU Z., BOĞA İ., ...More

Journal of Clinical Neurology (Korea), vol.19, no.3, pp.251-259, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 3
  • Publication Date: 2023
  • Doi Number: 10.3988/jcn.2022.0219
  • Journal Name: Journal of Clinical Neurology (Korea)
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, Directory of Open Access Journals
  • Page Numbers: pp.251-259
  • Keywords: balance disturbances, cognitive impairment, fall history, frailty, probable sarcopenia
  • Hacettepe University Affiliated: Yes


Background and Purpose Cognitive impairment is one of the main risk factors for falls, and hence it commonly coexists with balance issues. Frailty and sarcopenia are intertwined and prevalent in dementia, and are closely related to falls. We aimed to determine the relationships of the fall risk with balance disturbances, sarcopenia, and frailty in mild-to-moderate Alzheim-er’s disease (AD). Methods The study enrolled 56 patients with probable AD. A comprehensive geriatric assessment was performed, and muscle strength and mass, performance status, gait, and balance were evaluated. All parameters were compared between fallers and nonfallers with AD. Results Fallers comprised 53.6% of the study population. The demographic features and AD stages did not differ between fallers and nonfallers. Fallers were more frail than nonfallers (p<0.05). Frailty was found to be independently associated with fall history (odds ratio=2.15, 95% confidence interval=1.20–3.82, p=0.031). We found that falls were not associated with AD stage, muscle mass and function, balance and geriatric syndromes except urinary incontinence in patients with AD (p>0.05). Conclusions We found that falls were not influenced by AD stage. Both physical and cumula-tive frailty were strongly associated with falls in patients with mild-to-moderate AD.