Genetic background of Lewis negative blood group phenotype and its association with atherosclerotic disease in the NHLBI Family Heart Study

Salomaa, V; Pankow, J; Heiss, G; Cakir, BANU; Eckfeldt, JH; Ellison, RC; Myers, RH; Hiller, KM; Brantley, KR; Morris, TL; Weston, BW

doi:10.1046/j.1365-2796.2000.00682.x

Genetic background of Lewis negative blood group phenotype and its association with atherosclerotic disease in the NHLBI Family Heart Study

Salomaa V., Pankow J., Heiss G., Cakir B., Eckfeldt J., Ellison R., ...Daha Fazla

JOURNAL OF INTERNAL MEDICINE, cilt.247, sa.6, ss.689-698, 2000 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 247 Sayı: 6
Basım Tarihi: 2000
Doi Numarası: 10.1046/j.1365-2796.2000.00682.x
Dergi Adı: JOURNAL OF INTERNAL MEDICINE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.689-698
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Hacettepe Üniversitesi Adresli: Evet

Özet

Objectives. To examine the prevalence of four mutations, T59G, T1067A, T202C and C314T, of the human alpha(1,3/1,4) fucosyltransferase 3 (FUT 3) gene amongst persons with Lewis negative and those with Lewis positive blood group phenotype. An additional objective was to explore the hypothesis that these mutations are associated with coronary heart disease and inflammatory reaction.