Genetic background of Lewis negative blood group phenotype and its association with atherosclerotic disease in the NHLBI Family Heart Study

Salomaa, V; Pankow, J; Heiss, G; Cakir, BANU; Eckfeldt, JH; Ellison, RC; Myers, RH; Hiller, KM; Brantley, KR; Morris, TL; Weston, BW

doi:10.1046/j.1365-2796.2000.00682.x

Genetic background of Lewis negative blood group phenotype and its association with atherosclerotic disease in the NHLBI Family Heart Study

Salomaa V., Pankow J., Heiss G., Cakir B., Eckfeldt J., Ellison R., ...More

JOURNAL OF INTERNAL MEDICINE, vol.247, no.6, pp.689-698, 2000 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 247 Issue: 6
Publication Date: 2000
Doi Number: 10.1046/j.1365-2796.2000.00682.x
Journal Name: JOURNAL OF INTERNAL MEDICINE
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.689-698
Open Archive Collection: AVESIS Open Access Collection
Hacettepe University Affiliated: Yes

Abstract

Objectives. To examine the prevalence of four mutations, T59G, T1067A, T202C and C314T, of the human alpha(1,3/1,4) fucosyltransferase 3 (FUT 3) gene amongst persons with Lewis negative and those with Lewis positive blood group phenotype. An additional objective was to explore the hypothesis that these mutations are associated with coronary heart disease and inflammatory reaction.