Genetic background of Lewis negative blood group phenotype and its association with atherosclerotic disease in the NHLBI Family Heart Study

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Salomaa V., Pankow J., Heiss G., Cakir B., Eckfeldt J., Ellison R., ...Daha Fazla

JOURNAL OF INTERNAL MEDICINE, cilt.247, sa.6, ss.689-698, 2000 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 247 Sayı: 6
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1046/j.1365-2796.2000.00682.x
  • Dergi Adı: JOURNAL OF INTERNAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.689-698
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Objectives. To examine the prevalence of four mutations, T59G, T1067A, T202C and C314T, of the human alpha(1,3/1,4) fucosyltransferase 3 (FUT 3) gene amongst persons with Lewis negative and those with Lewis positive blood group phenotype. An additional objective was to explore the hypothesis that these mutations are associated with coronary heart disease and inflammatory reaction.