© 2016, Hacettepe University, Faculty of Pharmacy. All rights reserved.The human skin is an important organ that protects the organism against environmental factors and chemicals in the pharmaceutical formulations and cosmetic products. Skin irritation is the most common local toxic effect after exposure to cosmetic products. The potentials of the cosmetic products to induce skin irritation were evaluated by animal experiments in the past. In ethical terms, the irritation and skin corrosion tests have the potential to cause significant pain Since 3R principle was published, many alternative methods, which were validated and accepted by the regulatory authorities, have been developed for the evaluation of the potential toxic effects of the chemicals. On March 11, 2013, the commercial sale of any types of cosmetics and personal care products that were tested on animals was banned in the European Union; and since then, the safety evaluation of the cosmetics is being conducted with alternative in vitro toxicity tests. The in vitro restructured human epidermis tissue models are preferred as an alternative method because of their morphological similarity to the human skin. In this review, the traditional and alternative methods used for the evaluation of the irritation and corrosion potentials of cosmetic products are being discussed.