A case report of reversible intracranial lesions after long-term Azathioprine therapy in an autoimmune hepatitis patient

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Hasan A. A., Bulut E., KESKİN O.

Hepatology Forum, vol.4, no.2, pp.78-81, 2023 (Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 4 Issue: 2
  • Publication Date: 2023
  • Doi Number: 10.14744/hf.2023.2023.0006
  • Journal Name: Hepatology Forum
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.78-81
  • Keywords: Autoimmune hepatitis, azathioprine therapy, immunosuppressive drugs, reversible neural lesions
  • Hacettepe University Affiliated: Yes


This study is written to report a case of 67-year-old female with known autoimmune hepatitis (AIH) who developed balance and walking difficulties. Clinical and imaging investigations were more suggestive of AIH suffering from lymphoproliferative disease. To identify the underlying suspected lym-phoproliferative disease, series of brain scans were performed, which showed multiple brain lesions. This is a report on a striking case of multiple contrast enhanced brain lesions discovered in an AIH patient that was resolved upon withdrawal of azathioprine. Many side effects of azathioprine are acknowledged around the world; however, to the very best of our knowledge, an article on azathioprine inducing suspected malignancy was never reported.