Optimization of prednisolone acetate-loaded chitosan microspheres using a 2(3) factorial design for preventing restenosis

Sarisozen C., Arica B., ORMAN M. N., Hincal A. A., ÇALIŞ S.

DRUG DELIVERY, vol.17, no.3, pp.178-186, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 3
  • Publication Date: 2010
  • Doi Number: 10.3109/10717541003667780
  • Journal Name: DRUG DELIVERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.178-186
  • Hacettepe University Affiliated: Yes


Prednisolone acetate (PA)-loaded microspheres were prepared by the spray-drying technique using different polymer (1% and 2%) and drug concentrations (10% and 20%). To obtain the optimum formulation, a three-factor two-level (2