Leigh syndrome in a 3-year-old boy with unusual brain MR imaging and pathologic findings

Topcu M., Saatci I., Apak R., Soylemezoglu F., Akcoren Z.

AMERICAN JOURNAL OF NEURORADIOLOGY, vol.21, no.1, pp.224-227, 2000 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 1
  • Publication Date: 2000
  • Journal Name: AMERICAN JOURNAL OF NEURORADIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.224-227
  • Hacettepe University Affiliated: No

Abstract

We report unusual MR serial imaging and electron microscopy findings in a 3-year-old boy who had Leigh syndrome with cytochrome-c oxidase (cox) deficiency, The MR imaging findings included periventricular white matter involvement, posteroanterior progression, and extension through the corpus callosum and internal capsule; however, no basal ganglia or brain stem abnormality was found, which was suggestive of leukodystrophy. The most noteworthy findings were the cystic foci with contrast enhancement in the affected white matter.