Diagnosis and treatment of post radiotherapy locally recurrent prostate cancer is quite challenging for clinicians. Salvage treatment options in such cases are radical prostatectomy (SRP), cryotherapy (SCT), brachytherapy (SBT) and HIFU (SHIFU). Despite some retrospective studies, definitive conclusions can not be made about the superiority of these treatment options due to lack of prospective and comparative studies. SRP is a good option with its acceptable oncological outcomes and long follow up period compared to other minimally invasive methods. Challenges about the surgical technic and morbidities related with surgery are disadvantages of SRP. As well as open, laparoscopic and robotic approaches can also be performed. However, there isn't enough data to adequately compare the success of these approaches yet.