In vitro synergy of caspofungin and amphotericin B against Aspergillus and Fusarium spp.

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Arikan S., Lozano-Chiu M., Paetznick V., Rex J.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, cilt.46, sa.1, ss.245-247, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 1
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1128/aac.46.1.245-247.2002
  • Dergi Adı: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.245-247
  • Hacettepe Üniversitesi Adresli: Hayır

Özet

We investigated the in vitro interaction of caspofungin and amphotericin B for clinical isolates of Aspergillus and Fusarium. Synergy tests were performed using the checkerboard method and following the NCCLS M38-P guidelines in Antibiotic Medium 3 broth supplemented to 2% glucose. Antagonism was not observed for any of the isolates tested. Caspofungin and amphotericin B were synergistic or synergistic to additive for at least half of the isolates.