In vitro synergy of caspofungin and amphotericin B against Aspergillus and Fusarium spp.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol.46, no.1, pp.245-247, 2002 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 46 Issue: 1
- Publication Date: 2002
- Doi Number: 10.1128/aac.46.1.245-247.2002
- Journal Name: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.245-247
- Open Archive Collection: AVESIS Open Access Collection
- Hacettepe University Affiliated: No
Abstract
We investigated the in vitro interaction of caspofungin and amphotericin B for clinical isolates of Aspergillus and Fusarium. Synergy tests were performed using the checkerboard method and following the NCCLS M38-P guidelines in Antibiotic Medium 3 broth supplemented to 2% glucose. Antagonism was not observed for any of the isolates tested. Caspofungin and amphotericin B were synergistic or synergistic to additive for at least half of the isolates.