Serum zinc and alkaline phosphatase values in pediatric bone marrow transplantation patients

Uckan D., Cetin M., Dincer N., Kalkan G., Tuncer M., Tezcan I.

PEDIATRIC HEMATOLOGY AND ONCOLOGY, vol.20, no.4, pp.265-271, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 4
  • Publication Date: 2003
  • Doi Number: 10.1080/08880010390202450
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.265-271
  • Hacettepe University Affiliated: Yes


Zinc (Zn) plays an important role in the maintenance of immune functions, including cellular/ humoral immunity, and in the prevention of oxidative injury. Therefore, the maintenance of a normal Zn status may be important in bone marrow transplantation (BMT) patients. Serum Zn levels were determined in 35 children during the BMT period. In addition, as Zn-related factors, serum Cu levels and alkaline phosphatase (AP) activity were also measured. There was a significant decrease in Zn and AP values during the immediate post-transplant period (lowest at day +7) when compared to pre-BMT levels (p< .01). The patients who developed hypozincemia were more likely to be transplanted for a diagnosis of malignant disorder and were younger, and adverse events appeared to occur more frequently. This preliminary study suggests that maintaining a normal Zn status may be important in BMT patients and that Zn deficiency may be a risk factor for adverse events.