Lamotrigine augmentation in patients with schizophrenia who show partial response to clozapine treatment

Vayisoglu S., Yagcioglu A. E., Yagcioglu S., KARAHAN S., Karci O., GÜREL Ş. C., ...Daha Fazla

SCHIZOPHRENIA RESEARCH, cilt.143, sa.1, ss.207-214, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 143 Sayı: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.schres.2012.11.006
  • Dergi Adı: SCHIZOPHRENIA RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Sayfa Sayıları: ss.207-214
  • Anahtar Kelimeler: Schizophrenia, Clozapine, Augmentation, Lamotrigine, Mismatch negativity, EVENT-RELATED POTENTIALS, MISMATCH NEGATIVITY, DOUBLE-BLIND, RESISTANT SCHIZOPHRENIA, GLUTAMATE SYSTEM, RISPERIDONE, RELEVANCE, KETAMINE, EFFICACY, MEMORY
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Several placebo controlled studies investigating lamotrigine augmentation of clozapine in schizophrenia patients with partial response have shown varying results. The aim of this study was to further investigate the efficacy and safety of this augmentation strategy, and its effect on the glutamatergic system through utilizing mismatch negativity (MMN) component of auditory event related potentials.