Lamotrigine augmentation in patients with schizophrenia who show partial response to clozapine treatment

Vayisoglu S., Yagcioglu A. E., Yagcioglu S., KARAHAN S., Karci O., GÜREL Ş. C., ...More

SCHIZOPHRENIA RESEARCH, vol.143, no.1, pp.207-214, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 143 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.1016/j.schres.2012.11.006
  • Journal Name: SCHIZOPHRENIA RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Page Numbers: pp.207-214
  • Keywords: Schizophrenia, Clozapine, Augmentation, Lamotrigine, Mismatch negativity, EVENT-RELATED POTENTIALS, MISMATCH NEGATIVITY, DOUBLE-BLIND, RESISTANT SCHIZOPHRENIA, GLUTAMATE SYSTEM, RISPERIDONE, RELEVANCE, KETAMINE, EFFICACY, MEMORY
  • Hacettepe University Affiliated: Yes

Abstract

Background: Several placebo controlled studies investigating lamotrigine augmentation of clozapine in schizophrenia patients with partial response have shown varying results. The aim of this study was to further investigate the efficacy and safety of this augmentation strategy, and its effect on the glutamatergic system through utilizing mismatch negativity (MMN) component of auditory event related potentials.