Colchicine intolerance in FMF patients and primary obstacles for optimal dosing

Satis, Hasan; ARMAĞAN, BERKAN; Bodakci, Erdal; Atas, Nuh; SARI, ALPER; Yasar Bilge, Nazife; Yapar, Dilek; Bilici Salman, Reyhan; YARDIMCI, GÖZDE; BABAOĞLU, HAKAN; KILIÇ, LEVENT; Goker, Berna; HAZNEDAROĞLU, ŞEMİNUR; KAŞİFOĞLU, TİMUÇİN; KALYONCU, UMUT; TUFAN, ABDURRAHMAN

doi:10.3906/sag-2001-261

Colchicine intolerance in FMF patients and primary obstacles for optimal dosing

Satis H., ARMAĞAN B. , Bodakci E., Atas N., SARI A. , Yasar Bilge N. S. , ...More

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.50, no.5, pp.1337-1343, 2020 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 50 Issue: 5
Publication Date: 2020
Doi Number: 10.3906/sag-2001-261
Title of Journal : TURKISH JOURNAL OF MEDICAL SCIENCES
Page Numbers: pp.1337-1343
Keywords: Colchicine, side effect, intolerance, toxicity, dose, familial Mediterranean fever, RESISTANCE, MYOPATHY, THERAPY

Abstract

Background/aim: Colchicine is the mainstay of treatment in FMF. However, in daily practice it is not easy to maintain effective colchicine doses in a substantial number of patients due to its side effects. In this study, we aimed to investigate prevalence and risk factors for colchicine side effects that limit optimal drug dosing and cause permanent discontinuation.