Development of the autoinflammatory disease damage index (ADDI)


Ter Haar N. M. , Annink K. V. , Al-Mayouf S. M. , Amaryan G., Anton J., Barron K. S. , ...More

ANNALS OF THE RHEUMATIC DISEASES, vol.76, no.5, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 76 Issue: 5
  • Publication Date: 2017
  • Doi Number: 10.1136/annrheumdis-2016-210092
  • Title of Journal : ANNALS OF THE RHEUMATIC DISEASES

Abstract

Objectives Autoinflammatory diseases cause systemic inflammation that can result in damage to multiple organs. A validated instrument is essential to quantify damage in individual patients and to compare disease outcomes in clinical studies. Currently, there is no such tool. Our objective was to develop a common autoinflammatory disease damage index (ADDI) for familial Mediterranean fever, cryopyrin-associated periodic syndromes, tumour necrosis factor receptor-associated periodic fever syndrome and mevalonate kinase deficiency.