MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function

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Barbosa A. C., Kim M., Ertunc M., Adachi M., Nelson E. D., McAnally J., ...Daha Fazla

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, cilt.105, sa.27, ss.9391-9396, 2008 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 105 Sayı: 27
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1073/pnas.0802679105
  • Dergi Adı: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.9391-9396
  • Anahtar Kelimeler: synaptic transmission, synaptogenesis, learning deficits, ACTIVITY-DEPENDENT REGULATION, TRANSGENIC MICE, NERVOUS-SYSTEM, RADIAL GLIA, PLASTICITY, HIPPOCAMPUS, DIFFERENTIATION, EXPRESSION, CREB, MORPHOGENESIS
  • Hacettepe Üniversitesi Adresli: Hayır

Özet

Learning and memory depend on the activity-dependent structural plasticity of synapses and changes in neuronal gene expression. We show that deletion of the MEF2C transcription factor in the CNS of mice impairs hippocampal-dependent learning and memory. Unexpectedly, these behavioral changes were accompanied by a marked increase in the number of excitatory synapses and potentiation of basal and evoked synaptic transmission. Conversely, neuronal expression of a superactivating form of MEF2C results in a reduction of excitatory postsynaptic sites without affecting learning and memory performance. We conclude that MEF2C limits excessive synapse formation during activity-dependent refinement of synaptic connectivity and thus facilitates hippocampal-dependent learning and memory.