Computational assessment of SKA1 as a potential cancer biomarker

SUCULARLI C.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.44, sa.6, ss.752-760, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 6
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1515/tjb-2019-0148
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.752-760
  • Anahtar Kelimeler: Mitosis, Missense mutation, Prediction, Gene expression, Patient survival, GENE-EXPRESSION, MICROARRAY DATA, COMPLEX, METASTASIS, COMPONENT, SPINDLE, TOOL
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Spindle and kinetochore associated complex subunit 1 (SKA1) is an essential component of SKA complex, which is required for the proper formation of kinetochore-microtubule attachment and timely mitotic progression. The aim of this study is to perform detailed analyses of SKA1 genomic and expression alterations in cancers and to assess SKA1 as a biomarker for predicting human cancers and patient prognosis.