Computational assessment of SKA1 as a potential cancer biomarker

SUCULARLI C.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.44, no.6, pp.752-760, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 6
  • Publication Date: 2019
  • Doi Number: 10.1515/tjb-2019-0148
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.752-760
  • Keywords: Mitosis, Missense mutation, Prediction, Gene expression, Patient survival, GENE-EXPRESSION, MICROARRAY DATA, COMPLEX, METASTASIS, COMPONENT, SPINDLE, TOOL
  • Hacettepe University Affiliated: Yes

Abstract

Background: Spindle and kinetochore associated complex subunit 1 (SKA1) is an essential component of SKA complex, which is required for the proper formation of kinetochore-microtubule attachment and timely mitotic progression. The aim of this study is to perform detailed analyses of SKA1 genomic and expression alterations in cancers and to assess SKA1 as a biomarker for predicting human cancers and patient prognosis.