Nipecotic,acid, an uptake blocker, prevents fading of the γ-aminobutyric acid effect
Brain Research, cilt.366, sa.1-2, ss.314-319, 1986 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 366 Sayı: 1-2
- Basım Tarihi: 1986
- Doi Numarası: 10.1016/0006-8993(86)91309-0
- Dergi Adı: Brain Research
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.314-319
- Anahtar Kelimeler: hippocampus, muscimol, nipecotic acid, uptake blocker, γ-aminobutyric acid (GABA)
- Hacettepe Üniversitesi Adresli: Evet
Özet
In rats under urethane, ionotophoretic applications of GABA (30-60 nA) in the str. pyramide of CA1, showed a rapidly fading inhibitory effect. By contrast, GABA had a well-maintained inhibitory effect in str. radiatum. During iontophoresis of nipecotic acid (30-85 nA) identical applications of GABA in str. pyramidale caused a more prominent depression without fading, which suggests that removal of GABA, by uptake, can at least in part account for 'fading. Nipecotic acid also prolonged the paired-pulse inhibition, presumably by prolonging the duration of inhibitory postsynaptic potentials. © 1986.