Nipecotic,acid, an uptake blocker, prevents fading of the γ-aminobutyric acid effect

DALKARA T.

Brain Research, vol.366, no.1-2, pp.314-319, 1986 (Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 366 Issue: 1-2
  • Publication Date: 1986
  • Doi Number: 10.1016/0006-8993(86)91309-0
  • Journal Name: Brain Research
  • Journal Indexes: Scopus
  • Page Numbers: pp.314-319
  • Keywords: hippocampus, muscimol, nipecotic acid, uptake blocker, γ-aminobutyric acid (GABA)
  • Hacettepe University Affiliated: Yes

Abstract

In rats under urethane, ionotophoretic applications of GABA (30-60 nA) in the str. pyramide of CA1, showed a rapidly fading inhibitory effect. By contrast, GABA had a well-maintained inhibitory effect in str. radiatum. During iontophoresis of nipecotic acid (30-85 nA) identical applications of GABA in str. pyramidale caused a more prominent depression without fading, which suggests that removal of GABA, by uptake, can at least in part account for 'fading. Nipecotic acid also prolonged the paired-pulse inhibition, presumably by prolonging the duration of inhibitory postsynaptic potentials. © 1986.