Nipecotic,acid, an uptake blocker, prevents fading of the γ-aminobutyric acid effect

DALKARA T.

Brain Research, cilt.366, sa.1-2, ss.314-319, 1986 (Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 366 Sayı: 1-2
  • Basım Tarihi: 1986
  • Doi Numarası: 10.1016/0006-8993(86)91309-0
  • Dergi Adı: Brain Research
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.314-319
  • Anahtar Kelimeler: hippocampus, muscimol, nipecotic acid, uptake blocker, γ-aminobutyric acid (GABA)
  • Hacettepe Üniversitesi Adresli: Evet

Özet

In rats under urethane, ionotophoretic applications of GABA (30-60 nA) in the str. pyramide of CA1, showed a rapidly fading inhibitory effect. By contrast, GABA had a well-maintained inhibitory effect in str. radiatum. During iontophoresis of nipecotic acid (30-85 nA) identical applications of GABA in str. pyramidale caused a more prominent depression without fading, which suggests that removal of GABA, by uptake, can at least in part account for 'fading. Nipecotic acid also prolonged the paired-pulse inhibition, presumably by prolonging the duration of inhibitory postsynaptic potentials. © 1986.