Change in PsAID-12 scores in patients continuing or discontinuing anti-TNF treatments in psoriatic arthritis: results from the HUR-BIO biologic registry

KALYONCU U., KİRAZ S., APRAŞ BİLGEN Ş. Ş., KARADAĞ Ö., AKDOĞAN A., KILIÇ L., ...More

CLINICAL RHEUMATOLOGY, vol.38, no.4, pp.1187-1192, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 4
  • Publication Date: 2019
  • Doi Number: 10.1007/s10067-019-04426-3
  • Journal Name: CLINICAL RHEUMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1187-1192
  • Keywords: Anti-TNF treatment, Biological registry, PsAID-12, Psoriatic arthritis, ANKYLOSING-SPONDYLITIS, DISEASE-ACTIVITY, OUTCOME MEASURE, QUESTIONNAIRE, IMPACT, RECOMMENDATIONS, VALIDATION
  • Hacettepe University Affiliated: Yes

Abstract

ObjectivePsoriatic Arthritis Impact of Disease 12-item questionnaire (PsAID-12) has been developed to be used in psoriatic arthritis in daily practice. The aim of the present study was to assess the change values of PsAID-12 in PsA patients continuing or discontinuing anti-TNF treatment.MethodsWe recruited patients from the Hacettepe University biological database (HUR-BIO). Overall, 70 PsA patients had PsAID-12 score before the initiation of the first anti-TNF treatment. Stopping or switching the anti-TNF treatment due to inefficacy was definitely considered a negative response. Changes were evaluated by the comparison with the baseline PsAID-12 score in compliance with the favorable and unfavorable responses to anti-TNF treatments. The standardized response mean (SRM) was used for determining the response.ResultsSeventy (78.6% female) patients were analyzed and their mean age was 45.5years (12.0years). The mean follow-up duration was 18.3months (12.6months). At baseline, the mean PsAID-12 score was 6.6 (1.5). Physicians stopped or switched the treatment in 28 patients (40.0%) due to the inefficacy of anti-TNF treatment. The PsAID-12 score was 0.25 (1.71) in the patients discontinuing anti-TNF treatment and 3.52 (2.31) in the patients continuing their anti-TNF treatment (p<0.001). The SRM scores higher for PsAID-12, particularly in the well response to anti-TNF treatments.ConclusionA decrease of 3.5units in PsAID-12 score shows a favorable response to anti-TNF treatment. Changes in PsAID-12 score had well discrimination capacity for anti-TNF treatments.