Non-Invasive Separation of Alcoholic and Non-Alcoholic Liver Disease with Predictive Modeling

Sowa J., Atmaca O. , Kahraman A., Schlattjan M., Lindner M., Sydor S., ...More

PLOS ONE, vol.9, no.7, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 7
  • Publication Date: 2014
  • Doi Number: 10.1371/journal.pone.0101444
  • Title of Journal : PLOS ONE


Background & Objective: Currently, a major clinical challenge is to distinguish between chronic liver disease caused by metabolic syndrome (non-alcoholic fatty liver disease, NAFLD) from that caused by long term or excessive alcohol consumption (ALD). The etiology of severe liver disease affects treatment options and priorities for liver transplantation and organ allocation. Thus we compared physiologically similar NAFLD and ALD patients to detect biochemical differences for improved separation of these mechanistically overlapping etiologies.