Effects of rosiglitazone treatment on the pentose phosphate pathway and glutathione-dependent enzymes in liver and kidney of rats fed a high-fat diet


Akbay E., Ulusu N., Toruner F., Ayvaz G., Taneri F., Akturk M., ...Daha Fazla

CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, cilt.65, ss.79-89, 2004 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 65 Konu: 1
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1016/s0011-393x(04)90007-0
  • Dergi Adı: CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL
  • Sayfa Sayıları: ss.79-89

Özet

Background: Animals fed high-fat diets have been shown to develop hyperglycemia, insulin resistance, hyperlipidemia, and moderate obesity, which resemble the human metabolic syndrome. Obesity, the metabolic syndrome, and some thiazolidinediones, which act as insulin sensitizers, may increase oxidative stress, and/or influence the levels of cellular reducing equivalents and homeostasis.