Effects of rosiglitazone treatment on the pentose phosphate pathway and glutathione-dependent enzymes in liver and kidney of rats fed a high-fat diet

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Akbay E., Ulusu N., Toruner F., Ayvaz G., Taneri F., Akturk M., ...Daha Fazla

CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, cilt.65, sa.1, ss.79-89, 2004 (SCI-Expanded, Scopus)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 65 Sayı: 1
• Basım Tarihi: 2004
• Doi Numarası: 10.1016/s0011-393x(04)90007-0
• Dergi Adı: CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.79-89
• Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
• Hacettepe Üniversitesi Adresli: Hayır

Özet

Background: Animals fed high-fat diets have been shown to develop hyperglycemia, insulin resistance, hyperlipidemia, and moderate obesity, which resemble the human metabolic syndrome. Obesity, the metabolic syndrome, and some thiazolidinediones, which act as insulin sensitizers, may increase oxidative stress, and/or influence the levels of cellular reducing equivalents and homeostasis.