Enhanced oral absorption of paclitaxel in a novel self-microemulsifying drug delivery system with or without concomitant use of P-glycoprotein inhibitors

Yang, SC; Gursoy, RN; Lambert, G; Benita, S

doi:10.1023/b:pham.0000016238.44452.f1

Enhanced oral absorption of paclitaxel in a novel self-microemulsifying drug delivery system with or without concomitant use of P-glycoprotein inhibitors

Yang S., Gursoy R., Lambert G., Benita S.

PHARMACEUTICAL RESEARCH, vol.21, no.2, pp.261-270, 2004 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 21 Issue: 2
Publication Date: 2004
Doi Number: 10.1023/b:pham.0000016238.44452.f1
Title of Journal : PHARMACEUTICAL RESEARCH
Page Numbers: pp.261-270

Abstract

Purpose. The objective of this study was to evaluate the pharmacokinetics of paclitaxel in a novel self-microemulsifying drug delivery system (SMEDDS) for improved oral administration with or without P-glycoprotein (P-gp) inhibitors.