Enhanced oral absorption of paclitaxel in a novel self-microemulsifying drug delivery system with or without concomitant use of P-glycoprotein inhibitors

Yang S., Gursoy R., Lambert G., Benita S.

PHARMACEUTICAL RESEARCH, vol.21, no.2, pp.261-270, 2004 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 2
  • Publication Date: 2004
  • Doi Number: 10.1023/b:pham.0000016238.44452.f1
  • Journal Name: PHARMACEUTICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.261-270
  • Hacettepe University Affiliated: No

Abstract

Purpose. The objective of this study was to evaluate the pharmacokinetics of paclitaxel in a novel self-microemulsifying drug delivery system (SMEDDS) for improved oral administration with or without P-glycoprotein (P-gp) inhibitors.