Preparation and characterization of anticancer drug-loaded implantable PLGA microparticles


ÇETİN M., VURAL İ. , ATİLA A., Kadioglu Y.

TURKISH JOURNAL OF CHEMISTRY, vol.34, no.4, pp.509-516, 2010 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 4
  • Publication Date: 2010
  • Doi Number: 10.3906/kim-0910-237
  • Title of Journal : TURKISH JOURNAL OF CHEMISTRY
  • Page Numbers: pp.509-516

Abstract

This article describes the preparation and characterization of anticancer drug-loaded poly(lactide-co-glycolide) (PLGA) microparticles. PLGA microparticles loaded with doxorubicin HCl (DOX) were prepared via o/w emulsion solvent evaporation. The release characteristics, encapsulation efficiency, size, and morphology of the PLGA microparticles were also determined. A cytotoxicity test was performed by using Glioma RG2 cancer cells to investigate the cytotoxicity of DOX-loaded PLGA microparticles. The DOX-loaded PLGA microparticles had an average diameter of 500 +/- 9 nm. The DOX encapsulation efficiency and drug loading were 22.75% and 0.78%, respectively. DOX-loaded PLGA microparticles displayed a significant cytotoxicity toward the RG2 cells as compared to the unloaded PLGA microparticles.