The hematologic parameters in metastatic castration-resistant prostate cancer patients treated with abiraterone acetate


Onal C., Sedef A. M. , Kose F., Oymak E., Guler O. C. , Sumbul A. T. , ...More

FUTURE ONCOLOGY, vol.15, no.13, pp.1469-1479, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 13
  • Publication Date: 2019
  • Doi Number: 10.2217/fon-2018-0635
  • Title of Journal : FUTURE ONCOLOGY
  • Page Numbers: pp.1469-1479

Abstract

Currently, there are no predictive markers of response to abiraterone. We calculated neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) at baseline and at 4 and 12 weeks after initiation of abiraterone, and we evaluated prostate-specific antigen (PSA) response every 4 weeks in 102 metastatic castration-resistant prostate cancer (mCRPC) patients treated with abiraterone either pre-or postchemotherapy. With a median follow-up was 24.0 months (range: 0.3-54.9), median overall survival (OS) was 20.8 months. High-NLR patients who remained high or who returned to low NLR after 4 and 12 weeks showed significantly worse OS than patients with low baseline NLR. NLR and prostate-specific antigen response to abiraterone was a significant predictor of OS and progression-free survival (PFS) in metastatic castration-resistant prostate cancer patients treated with abiraterone delivered either pre-or postchemotherapy.