Maternal treatment with propofol attenuates lipid peroxidation after transient intrauterine ischemia in the neonatal rat brain

Solaroglu I., Okutan O., Solaroglu A., Kaptanoglu E., Beskonakli E., Kilinc K.

BIOLOGY OF THE NEONATE, vol.85, no.4, pp.221-224, 2004 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 85 Issue: 4
  • Publication Date: 2004
  • Doi Number: 10.1159/000075835
  • Title of Journal : BIOLOGY OF THE NEONATE
  • Page Numbers: pp.221-224


The purpose of this study was to investigate whether propofol has a neuroprotective effect on the fetal brain after intrauterine ischemia-reperfusion (I/R) injury in the rat fetus. Fetal brain ischemia was induced by clamping the utero-ovarian artery bilaterally for 30 min and reperfusion was achieved by removing the clamps for 2 h. A 40-mg/kg single dose of propofol was administered intraperitoneally 15 min before I/R injury. Lipid peroxidation in the brain tissue was determined as the concentration of thiobarbituric acid reactive substances (TBARS) for each fetal rat. Results showed that lipid peroxidation byproducts increased after I/R injury. Maternal treatment with propofol reduced TBARS compared to the I/R group. Propofol has been shown to have neuroprotective effects in intrauterine I/R-induced fetal brain damage in rats. Copyright (C) 2004 S. Karger AG, Basel.