Is neopterin level a predictive and differential biomarker in patients with thyroid disorders?

Sahin T. T. , Yuksel O., GİRGİN G. , Sipahi H., Dikmen K., Azili C., ...More

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, vol.32, no.2, pp.147-149, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 2
  • Publication Date: 2009
  • Doi Number: 10.1007/bf03345704
  • Page Numbers: pp.147-149
  • Keywords: Biomarker, neopterin, thyroid cancer, thyroid disorders, IMMUNE, ACTIVATION, EXPOSURE, FEMALES, MARKER


Neopterin production provides information about the extent of cellular immune activation. Measurement of neopterin levels may also provide predictive and prognostic information in patients with malignant thyroid diseases. In the present study, neopterin levels were investigated in patients with thyroid disorders (no.=68). Twenty-four patients had papillary thyroid cancers and the rest of them benign thyroid disorders. Results were compared with a healthy control group (no.=30). It was observed that there was a significant difference in neopterin levels between the control group and the thyroid disorders group (p<0.05). The mean neopterin levels in malignant and benign patients were also significantly different (p<0.05). Monitoring of urinary neopterin profile may be used in early diagnosis of papillary thyroid cancer. Neopterin seems to be a differential biomarker for malignant and benign thyroid disorders. (J. Endocrinol. Invest. 32: 147-149, 2009) (C) 2009, Editrice Kurtis