Effect of Increased Abdominal Pressure on Cytokines (IL1 beta, IL6, TNF alpha), C-reactive Protein (CRP), Free Radicals (NO, MDA), and Histology

Ozmen M. M., Zulfikaroglu B., Col C., Cinel I., Isman F. K., Cinel L., ...More

SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES, vol.19, no.2, pp.142-147, 2009 (SCI-Expanded) identifier identifier identifier


Background: It is generally accepted that proinflammatory mediators, including cytokines, are responsible for the metabolic changes associated with injury. Recent clinical and experimental studies have also shown that the laparoscopic procedures actually produce ischemia-reperfusion injury in the organs by oxygen-derived free radicals. This Study aimed to assess the effect of different insufflation pressures and laparotomy on tissue response by comparing the proinflammatory cytokines, C-reactive protein, and serum and tissue levels of oxygen-derived free radicals.