Effect of Increased Abdominal Pressure on Cytokines (IL1 beta, IL6, TNF alpha), C-reactive Protein (CRP), Free Radicals (NO, MDA), and Histology

Ozmen, Mahir; Zulfikaroglu, Baris; Col, Cavit; Cinel, Ismail; Isman, Ferruh; Cinel, Leyla; Besler, Tanju

doi:10.1097/sle.0b013e31819cdda7

Effect of Increased Abdominal Pressure on Cytokines (IL1 beta, IL6, TNF alpha), C-reactive Protein (CRP), Free Radicals (NO, MDA), and Histology

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Ozmen M. M., Zulfikaroglu B., Col C., Cinel I., Isman F. K., Cinel L., ...More

SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES, vol.19, no.2, pp.142-147, 2009 (SCI-Expanded)

Publication Type: Article / Article
Volume: 19 Issue: 2
Publication Date: 2009
Doi Number: 10.1097/sle.0b013e31819cdda7
Journal Name: SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.142-147
Hacettepe University Affiliated: Yes

Abstract

Background: It is generally accepted that proinflammatory mediators, including cytokines, are responsible for the metabolic changes associated with injury. Recent clinical and experimental studies have also shown that the laparoscopic procedures actually produce ischemia-reperfusion injury in the organs by oxygen-derived free radicals. This Study aimed to assess the effect of different insufflation pressures and laparotomy on tissue response by comparing the proinflammatory cytokines, C-reactive protein, and serum and tissue levels of oxygen-derived free radicals.