Transatlantic Lipid Guideline Divergence: Same Data But Different Interpretations

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Orringer C. E., Tokgozoglu L., Maki K. C., Ray K. K., Saseen J. J., Catapano A. L.

JOURNAL OF THE AMERICAN HEART ASSOCIATION, vol.9, no.21, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 9 Issue: 21
  • Publication Date: 2020
  • Doi Number: 10.1161/jaha.120.018189
  • Journal Name: JOURNAL OF THE AMERICAN HEART ASSOCIATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Hacettepe University Affiliated: Yes

Abstract

Despite consensus that excessive circulating concentrations of apoB-lipoproteins is a key driver for the atherosclerotic process and that treatments that low-density lipoprotein cholesterol lowering by up-regulation of low-density lipoprotein cholesterol receptor expression reduces that risk, divergent viewpoints on interpretation of study data have resulted in substantial differences in European and American lipid guideline recommendations. This article explores those differences and highlights the importance of understanding guideline-based lipid management to improve patient care and reduce the risk of clinical atherosclerotic cardiovascular disease.