Transatlantic Lipid Guideline Divergence: Same Data But Different Interpretations

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Orringer C. E., Tokgozoglu L., Maki K. C., Ray K. K., Saseen J. J., Catapano A. L.

JOURNAL OF THE AMERICAN HEART ASSOCIATION, cilt.9, sa.21, 2020 (SCI-Expanded, Scopus)

• Yayın Türü: Makale / Derleme
• Cilt numarası: 9 Sayı: 21
• Basım Tarihi: 2020
• Doi Numarası: 10.1161/jaha.120.018189
• Dergi Adı: JOURNAL OF THE AMERICAN HEART ASSOCIATION
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
• Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
• Hacettepe Üniversitesi Adresli: Evet

Özet

Despite consensus that excessive circulating concentrations of apoB-lipoproteins is a key driver for the atherosclerotic process and that treatments that low-density lipoprotein cholesterol lowering by up-regulation of low-density lipoprotein cholesterol receptor expression reduces that risk, divergent viewpoints on interpretation of study data have resulted in substantial differences in European and American lipid guideline recommendations. This article explores those differences and highlights the importance of understanding guideline-based lipid management to improve patient care and reduce the risk of clinical atherosclerotic cardiovascular disease.