Purpose: This study was planned with the aim of showing the effect of multi purposeful activity training on depression in the elderly who live at home and in the rest home. Material and methods: 34 elderly subjects staying in a rest home and 33 elderly subjects living at home aged 60 years and above participated in the study. Before and after activity training for testing depression, Yesavage's 30 point geriatric depression scale was used. Multi purposeful activities such as hand activities, locomotor activities and cognitive activities were performed two days a week for twelve weeks; each section lasted forty five minutes. The effects of group activity training in the rest home and individual training at home given according to the activity choices of the elderly and needs on depression were compared by appropriate statistical methods. Results: There were no differences in depression between first assessments of rest home and home group; this showed that the study was performed on two homogeneous groups (p>0.05). After activity training, decrease of depression in both groups was significant (p<0.05). Conclusion: Our study showed that amplifying activity variety, making the elderly desire the activity and creating possibilities for them to participate into activities regularly and continuously are topics which must be studied to decrease their depression.