Inhibition of Cerebral Vasoconstriction by Dantrolene and Nimodipine

Salomone S. , Soydan G., Moskowitz M. A. , Sims J. R.

NEUROCRITICAL CARE, cilt.10, sa.1, ss.93-102, 2009 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 10 Konu: 1
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1007/s12028-008-9153-0
  • Sayfa Sayıları: ss.93-102


Cerebral vasoconstriction is associated with increased cytosolic Ca2+ concentration in vascular smooth muscle, presumably due to Ca2+ influx and Ca2+ release from intracellular stores. We tested the hypothesis that dantrolene (a blocker of Ca2+-induced Ca2+ release from the ryanodine receptor channel on the sarco-endoplasmic reticulum) would potentiate the action of nimodipine (a voltage-dependent L-type Ca2+ channel blocker, considered standard therapy for SAH) in inhibiting the vasoconstriction of isolated cerebral arteries.