Inhibition of Cerebral Vasoconstriction by Dantrolene and Nimodipine


Salomone S. , Soydan G., Moskowitz M. A. , Sims J. R.

NEUROCRITICAL CARE, vol.10, no.1, pp.93-102, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 1
  • Publication Date: 2009
  • Doi Number: 10.1007/s12028-008-9153-0
  • Title of Journal : NEUROCRITICAL CARE
  • Page Numbers: pp.93-102

Abstract

Cerebral vasoconstriction is associated with increased cytosolic Ca2+ concentration in vascular smooth muscle, presumably due to Ca2+ influx and Ca2+ release from intracellular stores. We tested the hypothesis that dantrolene (a blocker of Ca2+-induced Ca2+ release from the ryanodine receptor channel on the sarco-endoplasmic reticulum) would potentiate the action of nimodipine (a voltage-dependent L-type Ca2+ channel blocker, considered standard therapy for SAH) in inhibiting the vasoconstriction of isolated cerebral arteries.