Anti-aging power of Rumex crispus L.: Matrixmetalloproteinases inhibitor, sun protective and antioxidant

Uzun M., Demirezer L. O.

SOUTH AFRICAN JOURNAL OF BOTANY, vol.124, pp.364-371, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 124
  • Publication Date: 2019
  • Doi Number: 10.1016/j.sajb.2019.05.028
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.364-371
  • Hacettepe University Affiliated: Yes


Skin aging is one of the major problems of the modern age. Matrixmetalloproteinases (MMPs) are responsible for breaking down extracellular matrix and cause of cell-aging. Ultraviolet (UV) rays and oxidants are also damage skin. Therefore, inhibition of MMP enzymes and higher sunscreen and antioxidant capacity should be a part of treatment strategy in preventing skin aging. The purpose of this study is to investigate the antiaging potential of Rumex crispus L. (Polygonaceae) extracts by determining MMP-1, MMP-8 and MMP-13 inhibitory effects, UV absorption and antioxidant capacities. In this study inhibitory effects of 15 extracts - with different polarities prepared from R. crispus - on MMP-1, MMP-8 and MMP-13 enzymes were determined. Antioxidant capacities were investigated by DPPH, ABTS, NO and phosphomolybdate methods and SPF values were calculated. Also, chemical profiles of extracts were evaluated by HPLC with the compounds we isolated. According to results, aqueous alcoholic extracts showed the highest inhibitory effect on all of MMP enzymes. Ethanol: water (70:30) extracts of roots, leaves and fruits showed high UV protection with SPF 13.56, 15.01 and 15.36 respectively. Total antioxidant capacities were in a range of 49,4%-86,4%. This study shows that Rumex crispus L. provides a valuable and powerful resource for anti-wrinkle, antioxidant and sunscreen cosmetic product. (C) 2019 SAAB. Published by Elsevier B.V. All rights reserved.