Antioxidant Effects of Secondary Metabolites from Geranium psilostemon

ŞÖHRETOĞLU D., Sabuncuoglu S. A., Sakar M. K., Ozgunes H., Sterner O.

NATURAL PRODUCT COMMUNICATIONS, vol.5, no.6, pp.899-902, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 5 Issue: 6
  • Publication Date: 2010
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.899-902
  • Hacettepe University Affiliated: Yes


An investigation was made of the effects on endogenous antioxidant enzyme activities and H(2)O(2)-induced lipid peroxidation inhibition in human red blood cells of the crude MeOH extract and its EtOAc, n-BuOH, and H(2)O sub-extracts obtained from aerial parts of Geranium psilostemon Ledeb., as well as compounds isolated from the most active EtOAc extract. Gallic acid (1), methyl gallate (2), pusilagin (3), 1,3,6-tri-O-galloyl-beta-glucopyranoside (4), 1,2,3,4,6-penta-O-galloyl-beta-glucopyranoside (5), kaempferol (6), quercetin (7), kaempferol 7-O-alpha-rhamnopyranoside (8), and quercetin 7-O-alpha-rhamnopyranoside (9) were isolated from the aerial parts of the title plant, and their structures identified from spectroscopic (UV, 1D- and 2D- NMR) and spectrometric (TOF-MS) data. All extracts and isolated compounds inhibited H(2)O(2)-induced lipid peroxidation and also enhanced the activity of superoxide dismutase (SOD) and catalase (CAT).