Osteoporosis constitutes a major public health problem and health consequences from osteoporotic fractures in patients include disability having a negative impact on the quality of life. Physical, emotional, and psychological incapacity, combined with the pain that results from hip, spine, or wrist fractures, can alter quality of life. Even in the absence of fragility fractures osteoporotic patients have substantially lower quality of life scales. Quality of life in men and women with osteoporosis should be thoroughly investigated even prior to the occurrence of fracture, to develop appropriate interventions that would empower patients to effectively manage all stages of the disease. Also assessing quality of life is essential to health research and clinical trials involving osteoporosis. And the choice of the instrument used to assess quality of life depends on the type of research and on the research question asked; each instrument has specific advantages and disadvantages. The Quality of Life Questionnaire of the European Foundation for Osteoporosis and the Osteoporosis Quality of Life Questionnaire are targeted more toward fracture assessment, and the Osteoporosis Functional Disability Questionnaire can be used for longitudinal studies involving exercise. It is stated that, the huge burden caused by osteoporosis related fractures to individuals, healthcare systems and societies should provide a clear impetus for the progression of such approaches and assessment of quality of life seems to be an essential initial step.