Increased mean corpuscular volume of erythrocytes during capecitabine treatment: a simple surrogate marker for clinical response


ARSLAN Ç. , AKSOY S. , DİZDAR Ö. , KURT M. , Guler N., Ozisik Y., ...Daha Fazla

TUMORI, cilt.97, ss.711-716, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 97 Konu: 6
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1700/1018.11086
  • Dergi Adı: TUMORI
  • Sayfa Sayıları: ss.711-716

Özet

Aims and background. Capecitabine, as all fluoropyrimidines, interferes with vitamin metabolism and may thus have an impact on hematopoiesis. It is metabolized to its active form 5-fluoruracil by the enzyme thymidine phosphorylase, which exists in higher concentrations in tumor tissue and liver than in normal tissues. In the study, we investigated the changes in mean corpuscular volume (MCV) of red blood cells and the possible correlation of these changes with the clinical outcome of capecitabine treatment in women with metastatic breast cancer.