Is endothelial glycocalyx damage a cause of renal scarring in vesicoureteral reflux with febrile urinary tract infection?

AKARKEN İ., TARHAN H., Arslan F. D., Saritas S., Yavascan O., ŞAHİN H., ...More

NEPHROLOGIE & THERAPEUTIQUE, vol.17, no.3, pp.175-179, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.1016/j.nephro.2021.01.003
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, EMBASE, MEDLINE
  • Page Numbers: pp.175-179
  • Hacettepe University Affiliated: Yes


Introduction. - Endothelial glycocalyx is a luminal layer which can be damaged by inflammatory agents or pathogens. The endothelial glycocalyx damage is thought to have a role in the formation of renal scars in children who have febrile urinary tract infection and vesicoureteral reflux. This study aimed to compare the blood levels of endothelial glycocalyx components heparan sulfate and Syndecan-1 in children with and without renal scarring due to vesicoureteral reflux-associated febrile urinary tract infection.