Potential Role of Lycopene in the Treatment of Hepatitis C and Prevention of Hepatocellular Carcinoma

Seren, Soley; Mutchnick, Milton; Hutchinson, Daryl; HARMANCI, ÖZGÜR; BAYRAKTAR, YUSUF; Mutchnick, Sean; ŞAHİN, KAZİM; Kucuk, Omer

doi:10.1080/01635580802419772

Potential Role of Lycopene in the Treatment of Hepatitis C and Prevention of Hepatocellular Carcinoma

Seren S., Mutchnick M., Hutchinson D., HARMANCI Ö., BAYRAKTAR Y., Mutchnick S., ...Daha Fazla

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, cilt.60, sa.6, ss.729-735, 2008 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 60 Sayı: 6
Basım Tarihi: 2008
Doi Numarası: 10.1080/01635580802419772
Dergi Adı: NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.729-735
Hacettepe Üniversitesi Adresli: Evet

Özet

Hepatitis C virus (HCV) infection and hepatocellular carcinoma (HCC) are growing health problems around the world. Oxidative stress plays a significant role in the initiation and progression of hepatocellular damage and possibly in the development of HCC in HCV infected patients. In vitro, animal and clinical studies suggest that lycopene, a nonprovitamin A carotenoid and a potent antioxidant, may attenuate the liver injury and possibly prevent the development of HCC. In this article, we discuss the relationship between HCV infection and oxidative stress and review the potential role of lycopene in the treatment of HCV and prevention of HCC.