An Efficient Synthetic Route for Pyrrolizinone Synthesis through Functionalized C-Alkylpyrroles

ÜNALEROĞLU C., Tasgin D. I., Aytac S., TEMELLİ B.

SYNTHESIS-STUTTGART, no.19, pp.3243-3250, 2009 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2009
  • Doi Number: 10.1055/s-0029-1216951
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.3243-3250
  • Hacettepe University Affiliated: Yes


Regioselective addition of pyrrole to methyl 3-aryl-2-cyanoacrylates was achieved, in high yields, with copper(II) triflate as the catalyst in toluene. C-Alkylated pyrroles afforded novel pyrrolizin-3-ones, in good to high yields and high diastereomeric ratio by an intramolecular cyclization reaction under mild reaction conditions.