Studies on calcium modulatory activities of 2,6,6-trimethyl-3-acetyl-4-aryl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, cilt.49, sa.10, ss.824-829, 1999 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 49 Sayı: 10
- Basım Tarihi: 1999
- Dergi Adı: ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.824-829
- Hacettepe Üniversitesi Adresli: Evet
Özet
Twenty-two new 2,6,6-trimethyl-3-acetyl-4-aryl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives (compounds 1-22) have been prepared. The structures of the compounds were characterised by IR, H-1-NMR, mass spectroscopy and elemental analyses. The calcium antagonistic activities of the compounds were determined by the tests performed on isolated rabbit ileum and lamb carotid artery. According to the isolated rabbit ileum activity tests the most active compounds an 10 and 12 and according to the lamb carotid activity tests the most active compounds are 6 and 10.