A link between cytotoxicity in cell culture and gastrointestinal side effects of oral anticoagulants: bench-to-bedside

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Kubat E., Gurpinar O. A., Karasoy D., Onur M. A.

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, cilt.119, sa.11, ss.706-712, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 119 Sayı: 11
  • Basım Tarihi: 2018
  • Doi Numarası: 10.4149/bll_2018_126
  • Dergi Adı: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.706-712
  • Anahtar Kelimeler: dabigatran, rivaroxaban, apixaban, warfarin, cell viability, WARFARIN, DABIGATRAN
  • Hacettepe Üniversitesi Adresli: Evet

Özet

OBJECTIVE: Warfarin and nonvitamin-K oral anticoagulants including dabigatran, rivaroxaban, and apixaban are commonly used in the prophylaxis and treatment of systemic embolism and deep vein thrombosis. In this study, we aimed to compare the cytotoxic effects of warfarin and new oral anticoagulants and to show a possible correlation between cell cytotoxicity and gastrointestinal side effects in the real-life setting.