Serum Total Sialic Acid and Lipid-linked Sialic Acid May Be the New Potential Biomarkers in Paracetamol Nephrotoxicity

Oksuz E., Bugday M. S., Demir F., Ekin S., Arihan O., Oto G.

TURKISH JOURNAL OF NEPHROLOGY, vol.29, no.4, pp.273-278, 2020 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.5152/turkjnephrol.2020.4310
  • Journal Name: TURKISH JOURNAL OF NEPHROLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.273-278
  • Keywords: Paracetamol, nephropathy, sialic acid, acetaminophen, kidney injury, ACETAMINOPHEN NEPHROTOXICITY, OXIDATIVE STRESS, EXTRACT
  • Hacettepe University Affiliated: Yes

Abstract

Objective: In recent years, paracetamol has been shown to have toxic effects on the kidneys. Sialic acid (SA), an important component of the cell membranes, increases in many pathological conditions. This study aimed to investigate the effects of different doses of paracetamol on the kidney tissue and serum total SA (TSA) and lipid-bound SA (LSA) levels.