Reduced myelin in patients with isolated hippocampal sclerosis as assessed by SyMRI.


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PARLAK Ş., ÇOBAN ÇİFÇİ G., GÜMELER E., KARAKAYA KARABULUT J., Soylemezoglu F., TEZER FİLİK F. İ. , ...More

Neuroradiology, vol.64, no.1, pp.99-107, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 64 Issue: 1
  • Publication Date: 2022
  • Doi Number: 10.1007/s00234-021-02824-6
  • Journal Name: Neuroradiology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Biotechnology Research Abstracts, CINAHL, EMBASE, MEDLINE
  • Page Numbers: pp.99-107
  • Keywords: Synthetic MRI, Hippocampal sclerosis, Myelin, Epilepsy, TEMPORAL-LOBE EPILEPSY, WHITE-MATTER CHANGES, SYNTHETIC MRI, MULTIPLE-SCLEROSIS, BRAIN, NEUROPATHOLOGY, ABNORMALITY, TISSUE
  • Hacettepe University Affiliated: Yes

Abstract

Purpose Synthetic MRI (SyMRI) enables to quantify brain tissue and morphometry. We aimed to investigate the WM and myelin alterations in patients with unilateral hippocampal sclerosis (HS) with SyMRI. Methods Adult patients with isolated unilateral HS and age-matched control subjects (CSs) were included in this study. The SyMRI sequence QRAPMASTER in the coronal plane perpendicular to the hippocampi was obtained from the whole brain. Automatic segmentation of the whole brain was processed by SyMRI Diagnostic software (Version 11.2). Two neuroradiologists also performed quantitative analyses independently from symmetrical 14 ROIs placed in temporal and extratemporal WM, hippocampi, and amygdalae in both hemispheres. Results Sixteen patients (F/M = 6/10, mean age = 32.5 +/- 11.3 years; right/left HS: 8/8) and 10 CSs (F/M = 5/5, mean age = 30.7 +/- 7 years) were included. Left HS patients had significantly lower myelin and WM volumes than CSs (p < .05). Myelin was reduced significantly in the ipsilateral temporal lobe of patients than CSs, greater in left HS (p < .05). Histopathological examination including luxol fast blue stain also revealed myelin pallor in all of 6 patients who were operated. Ipsilateral temporal pole and sub-insular WM had significantly reduced myelin than the corresponding contralateral regions in patients (p < .05). No significant difference was found in WM values. GM values were significantly lower in hippocampi in patients than CSs (p < .05). Conclusion SyMRI revealed myelin reduction in the ipsilateral temporal lobe and sub-insular WM of patients with HS. Whether this finding correlates with electrophysiological features and SyMRI could serve as lateralization of temporal lobe epilepsy need to be investigated.