A histopathologicai investigation on the effect of systemic administration of the bisphosphonate alendronate on resorptive phase following mucoperiosteal flap surgery in the rat mandible


Kaynak D., Meffert R., Bostanci H., Gunhan O., Ozkaya Ö.

JOURNAL OF PERIODONTOLOGY, vol.74, no.9, pp.1348-1354, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 74 Issue: 9
  • Publication Date: 2003
  • Doi Number: 10.1902/jop.2003.74.9.1348
  • Journal Name: JOURNAL OF PERIODONTOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1348-1354
  • Hacettepe University Affiliated: Yes

Abstract

Background: The present study was designed to assess histopathologically whether the systemic administration of aminobisphosphonate (alendronate), 0.5 mg/kg body weight, is effective in preventing alveolar bone resorption following mucoperiosteal flap surgery, and whether alendronate modulates tissue factors.