Levels of pro- and anti-inflammatory cytokines in cystic fibrosis patients with or without gingivitis.

Duruel O., Berker E., Özşin-Özler C., Gharibzadeh-Hızal M., Gürpınar Ö., Eryılmaz-Polat S., ...Daha Fazla

Cytokine, cilt.127, ss.154987, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 127
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.cyto.2020.154987
  • Dergi Adı: Cytokine
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.154987
  • Anahtar Kelimeler: Cytokine, Cystic fibrosis, ELISA, Gingival crevicular fluid, Periodontal status, TRANSMEMBRANE CONDUCTANCE REGULATOR, PSEUDOMONAS-AERUGINOSA, CREVICULAR FLUID, PERIODONTAL-DISEASE, PATHOGENESIS, EXPRESSION, RECEPTOR, SODIUM, CFTR
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Inflammatory periodontal diseases are caused by interaction between gram negative, anaerobic bacteria and host response. Persistent infection of Pseudomonas aeruginosa in cystic fibrosis (CF) patients also cause increased pro-inflammatory response and the imbalance of pro- and anti-inflammatory response in bro-choalveolar lavage fluid which leads to destruction of lungs. The aim of this study is to evaluate periodontal status of CF patients, to measure level of cytokines and biochemical molecules in gingival crevicular fluid (GCF), and to detect presence of P. aeruginosa in dental plaque samples.