It was estimated that, total number of adults with hypertension was approximately 1 billion worldwide. This number was predicted to increase to a total of 1.5 billion in 2025. Hypertension is the most important risk factor for cardiovascular morbidity and mortality. The relationship between blood pressure and risk of cardiovascular events is continuous, consistent, and independent of other risk factors. The higher the blood pressure, the greater the possibility of heart attack, heart failure, stroke, and kidney diseases. The main purpose of hypertension treatment is to reduce the cardiovascular and renal morbidity and mortality. In this review, the principles of pharmalogical therapy and evolving role of angiotension receptor blockers in hypertension will be summarised according to recent guidelines.