A case of interleukin-12 receptor beta-1 deficiency with recurrent leishmaniasis


Sanal O., Turkkani G., Gumruk F. , Yel L., Secmeer G., Tezcan I., ...More

PEDIATRIC INFECTIOUS DISEASE JOURNAL, vol.26, no.4, pp.366-368, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 4
  • Publication Date: 2007
  • Doi Number: 10.1097/01.inf.0000258696.64507.0f
  • Title of Journal : PEDIATRIC INFECTIOUS DISEASE JOURNAL
  • Page Numbers: pp.366-368

Abstract

Interleukin-12 receptor beta-1 (IL-12R beta 1) defect is generally associated with selective susceptibility to weakly pathogenic mycobacteria and Salmonella species. Patients rarely experience infections caused by other organisms. We report a 5-year-old patient with IL-12R beta 1 deficiency who developed recurrent visceral leishmaniasis 6 months apart. The patient responded to lyposomal amphotericin B treatment reasonably well.