A case of interleukin-12 receptor beta-1 deficiency with recurrent leishmaniasis

Sanal, Ozden; Turkkani, Gulten; Gumruk, FATMA; Yel, Leman; Secmeer, Gulten; Tezcan, Ilhan; Kara, ATEŞ; Ersoy, Fugen

doi:10.1097/01.inf.0000258696.64507.0f

A case of interleukin-12 receptor beta-1 deficiency with recurrent leishmaniasis

Sanal O., Turkkani G., Gumruk F., Yel L., Secmeer G., Tezcan I., ...Daha Fazla

PEDIATRIC INFECTIOUS DISEASE JOURNAL, cilt.26, sa.4, ss.366-368, 2007 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 26 Sayı: 4
Basım Tarihi: 2007
Doi Numarası: 10.1097/01.inf.0000258696.64507.0f
Dergi Adı: PEDIATRIC INFECTIOUS DISEASE JOURNAL
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.366-368
Hacettepe Üniversitesi Adresli: Evet

Özet

Interleukin-12 receptor beta-1 (IL-12R beta 1) defect is generally associated with selective susceptibility to weakly pathogenic mycobacteria and Salmonella species. Patients rarely experience infections caused by other organisms. We report a 5-year-old patient with IL-12R beta 1 deficiency who developed recurrent visceral leishmaniasis 6 months apart. The patient responded to lyposomal amphotericin B treatment reasonably well.