A case of interleukin-12 receptor beta-1 deficiency with recurrent leishmaniasis

Sanal O., Turkkani G., Gumruk F., Yel L., Secmeer G., Tezcan I., ...More

PEDIATRIC INFECTIOUS DISEASE JOURNAL, vol.26, no.4, pp.366-368, 2007 (SCI-Expanded) identifier identifier identifier


Interleukin-12 receptor beta-1 (IL-12R beta 1) defect is generally associated with selective susceptibility to weakly pathogenic mycobacteria and Salmonella species. Patients rarely experience infections caused by other organisms. We report a 5-year-old patient with IL-12R beta 1 deficiency who developed recurrent visceral leishmaniasis 6 months apart. The patient responded to lyposomal amphotericin B treatment reasonably well.