New analgesic and antiinflammatory agents 4(1H)-pyridinone derivatives
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, cilt.37, sa.10, ss.829-834, 2002 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 37 Sayı: 10
- Basım Tarihi: 2002
- Doi Numarası: 10.1016/s0223-5234(02)01390-9
- Dergi Adı: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.829-834
- Hacettepe Üniversitesi Adresli: Evet
Özet
series of 1,2,5-trisubstituted 4(1H)-pyridinone derivatives (7-14) were synthesised by using 4-pyrone derivatives with primary amines in ethanol. The structures of the synthesised compounds were confirmed by analytical and spectral data (UV, IR and 1H-NMR and microanalysis). Analgesic and antiinflammatory activities of the synthesised compounds were investigated by acetic acid-induced writhing syndrome and carrageenan rat paw edema tests. All of the test compounds exhibited higher analgesic activities than acetyl salicylic acid and showed higher antiinflammatory activities than indomethacin. The anti-inflammatory activity and gastric ulceration potential of the compounds were tested using indomethacin as reference drug. (C) 2002 Published by Editions scientifiques et medicales Elsevier SAS.