Background: Burn injuries in childhood create serious trauma for both children and their caregivers. Burn injuries require extensive nursing care to reduce complications and to restore optimal functional health conditions. When children receive burn treatment and their caregivers are migrants with different languages, religions, and habits, nurses must adopt a cultural approach while caring for such patients. Aim: This descriptive qualitative study aimed to reveal the challenges, expectations, and cultural care experiences of nurses regarding migrant children receiving burn treatment and their caregivers. Method: Purposive sampling was used to recruit the nurses (n = 12). Semi-structured face-to-face interviews were conducted with nurses using an interview guide, and the interviews were recorded. Thematic analysis was used to create themes in the study. Results: The data were gathered around three main themes: “challenges” with the subcategories “communication,” “trust relationship,” and “care burden”; “expectations for better care” with the subcategories “translator support” and “hospital environment”; and “intercultural care” with the subcategories “cultural-religious differences” and “intercultural sensitivity.” Conclusions: The results of this study provide a novel insight into nurses’ experiences with migrant child patients and their caregivers, and can be used to develop action plans to provide effective cultural care for patients receiving burn treatment and their caregivers.