Therapeutic applications of mitochondrial transplantation

Ulger O., Kubat G. B.

Biochimie, vol.195, pp.1-15, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 195
  • Publication Date: 2022
  • Doi Number: 10.1016/j.biochi.2022.01.002
  • Journal Name: Biochimie
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.1-15
  • Keywords: Mitochondria dysfunction, Mitochondrial transplantation, Mitochondrial dynamics, Mitochondrial isolation
  • Hacettepe University Affiliated: Yes

Abstract

© 2022 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM)This review aims to make a framework of exogenous healthy mitochondrial transplantation and to assemble present information for improving new therapeutic applications in a variety of diseases. Recently, the significance of mitochondrial transplantation has been emphasized in a variety of mitochondrial dysfunction-related diseases such as neurodegenerative diseases, toxic injury, ischemia, cardiovascular diseases. We describe the natural mitochondrial transfer mechanisms (ie. TNT, EVs, mitochondrial dynamics), mitochondrial isolation process for transplantation (ie. source of mitochondria, requirements for successful isolation), mitochondrial transplantation methods (in vivo, in vitro), the effects and limitations of mitochondrial transplantation. Since mitochondrial transplantation is seen as an innovative potential treatment for diseases that can not be treated at the desired level, we expect to represent how the mitochondrial transplantation methods can be used in different diseases.