Ligand-induced expression of peroxisome proliferator-activated receptor alpha and activation of fatty acid oxidation enzymes in fatty liver

Akbiyik, FİLİZ; Cinar, K; Demirpence, E; Ozsullu, T; Tunca, R; Haziroglu, R; Yurdaydin, C; Uzunalimoglu, O; Bozkaya, H

doi:10.1111/j.1365-2362.2004.01359.x

Ligand-induced expression of peroxisome proliferator-activated receptor alpha and activation of fatty acid oxidation enzymes in fatty liver

Akbiyik F., Cinar K., Demirpence E., Ozsullu T., Tunca R., Haziroglu R., ...Daha Fazla

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, cilt.34, sa.6, ss.429-435, 2004 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 34 Sayı: 6
Basım Tarihi: 2004
Doi Numarası: 10.1111/j.1365-2362.2004.01359.x
Dergi Adı: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.429-435
Hacettepe Üniversitesi Adresli: Evet

Özet

Background Peroxisome proliferator-activated receptor alpha (PPARalpha) regulates lipid metabolism upon activation by ligands. Peroxisome proliferator-activated receptor alpha may play a role in the pathogenesis of fatty liver disease. The aim of this study was to assess the PPARalpha expression pattern and mitochondrial/peroxisomal enzyme activities in response to high fat diet (HFD) and clofibrate, a well known PPARalpha ligand.