Ligand-induced expression of peroxisome proliferator-activated receptor alpha and activation of fatty acid oxidation enzymes in fatty liver

Akbiyik F., Cinar K., Demirpence E., Ozsullu T., Tunca R., Haziroglu R., ...More

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, vol.34, no.6, pp.429-435, 2004 (SCI-Expanded) identifier identifier identifier


Background Peroxisome proliferator-activated receptor alpha (PPARalpha) regulates lipid metabolism upon activation by ligands. Peroxisome proliferator-activated receptor alpha may play a role in the pathogenesis of fatty liver disease. The aim of this study was to assess the PPARalpha expression pattern and mitochondrial/peroxisomal enzyme activities in response to high fat diet (HFD) and clofibrate, a well known PPARalpha ligand.