Ligand-induced expression of peroxisome proliferator-activated receptor alpha and activation of fatty acid oxidation enzymes in fatty liver


Akbiyik F. , Cinar K., Demirpence E., Ozsullu T., Tunca R., Haziroglu R., ...Daha Fazla

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, cilt.34, ss.429-435, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 34 Konu: 6
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1111/j.1365-2362.2004.01359.x
  • Dergi Adı: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
  • Sayfa Sayıları: ss.429-435

Özet

Background Peroxisome proliferator-activated receptor alpha (PPARalpha) regulates lipid metabolism upon activation by ligands. Peroxisome proliferator-activated receptor alpha may play a role in the pathogenesis of fatty liver disease. The aim of this study was to assess the PPARalpha expression pattern and mitochondrial/peroxisomal enzyme activities in response to high fat diet (HFD) and clofibrate, a well known PPARalpha ligand.