Ligand-induced expression of peroxisome proliferator-activated receptor alpha and activation of fatty acid oxidation enzymes in fatty liver

Akbiyik, FİLİZ; Cinar, K; Demirpence, E; Ozsullu, T; Tunca, R; Haziroglu, R; Yurdaydin, C; Uzunalimoglu, O; Bozkaya, H

doi:10.1111/j.1365-2362.2004.01359.x

Ligand-induced expression of peroxisome proliferator-activated receptor alpha and activation of fatty acid oxidation enzymes in fatty liver

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Akbiyik F., Cinar K., Demirpence E., Ozsullu T., Tunca R., Haziroglu R., ...More

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, vol.34, no.6, pp.429-435, 2004 (SCI-Expanded)

Publication Type: Article / Article
Volume: 34 Issue: 6
Publication Date: 2004
Doi Number: 10.1111/j.1365-2362.2004.01359.x
Journal Name: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.429-435
Hacettepe University Affiliated: Yes

Abstract

Background Peroxisome proliferator-activated receptor alpha (PPARalpha) regulates lipid metabolism upon activation by ligands. Peroxisome proliferator-activated receptor alpha may play a role in the pathogenesis of fatty liver disease. The aim of this study was to assess the PPARalpha expression pattern and mitochondrial/peroxisomal enzyme activities in response to high fat diet (HFD) and clofibrate, a well known PPARalpha ligand.