Evaluation of the analgesic and anti-inflammatory activities of some thiazolo[4,5-d]pyrimidines


BALKAN A. , Gören Z., Urgun H., Çaliş Ü., ÇAKAR A. , ATİLLA P. , ...Daha Fazla

Arzneimittel-Forschung/Drug Research, cilt.52, sa.6, ss.462-467, 2002 (SCI Expanded İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 52 Konu: 6
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1055/s-0031-1299915
  • Dergi Adı: Arzneimittel-Forschung/Drug Research
  • Sayfa Sayıları: ss.462-467

Özet

Some thiazolo[4,5-d]pyrimidine-7(6H)-one derivatives were evaluated in vivo for their analgesic and anti-inflammatory activities. The results were compared with that of acetyl salicylic acid and phenylbutazone. Compounds 3b and 3h were the most active in the anti-inflammatory paw edema inhibition test. In terms of the analgesic activity (acetic acid writhing test), the most active compound was 2a followed by 31. The most active members of the series were investigated for their ED50 values and ulcerogenic potential.